Journal: Magnetic resonance in medicine
Article Title: Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard
doi: 10.1002/mrm.28825
Figure Lengend Snippet: Schematic sketch of the Pulseq-CEST hybrid sequence playing out the preparation period of protocol APTw_3T_002. A) Format of the pulseq-file with channels for time delay, RF pulse, gradient, ADC and trigger events. The numbers link to entries in a lookup table where the actual event parameters are defined. Note that the RF pulses have the same amplitude and frequency offset, but a different ID due to different phase offsets. B) Example GRE readout sequence. C) Proposed combination of Pulseq events and the readout block using Pulseq as an SBB. RF events appear at blocks number 36, 38, and 40; spoiler gradients at block number 41 and delay events at blocks number 37 and 39. All Pulseq-CEST RF events are spatially non-selective. Blue crosses on the RF phase plots mark the RF phase at the moment of time when the peak RF magnitude is reached. For simplicity, GY and GZ gradient axes are not shown here. At every ADC event in the pulseq-file (block number 42), the GRE readout is played out.
Article Snippet: In this work, we implemented such a hybrid Pulseq -CEST sequence for the Siemens IDEA (Integrated Development Environment for Applications, Siemens Healthineers, Erlangen, Germany) framework and tested it on three Siemens scanners at three sites, with two scanner models running very different software baselines.
Techniques: Sequencing, Blocking Assay